Temperature-Sensitive Mutants of Influenza A Virus. XI. Transfer of ts Lesions in the Hong Kong/68-ts-l [A] Virus to the Influenza A/Udorn/72 Wild Type
Identifieur interne : 002B17 ( Main/Exploration ); précédent : 002B16; suivant : 002B18Temperature-Sensitive Mutants of Influenza A Virus. XI. Transfer of ts Lesions in the Hong Kong/68-ts-l [A] Virus to the Influenza A/Udorn/72 Wild Type
Auteurs : Brian R. Murphy [États-Unis] ; Eveline L. Tierney [États-Unis] ; Susan B. Spring [États-Unis] ; Robert M. Chanock [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1976.
Abstract
The presence of the temperature-sensitive (ts) lesions of complementation-recombination groups I and 5 in the Hong Kong/68-ts-I[A] virus was confirmed by genetic analysis of ts recombinants of the Hong Kongj68-ts-1 [A] virus and a Udorn / 72 wildtype virus. Three classes of Udorn/72-ts recombinants were found. One class possessed both ts genes of the Hong Kong/68-ts-I[A] parent, a second class possessed the ts lesion characteristic of group I, and a third class possessed the ts lesion of group 5. The Hong Kongj68-ts-1 [AJ parent and the Udorn/72-ts recombinants exhibited a lO,OOO-fold or greater restriction of replication in the lungs of hamsters than did the homologous wild-type virus. All isolates from the lungs and nasal turbinates of recipients of two of the four Udorn/72-ts-I[AJ recombinants contained only ts virus. These two properties, restricted replication and genetic stability after replication in vivo, suggest that the Udorn/72-ts-I[AJ recombinants should be considered for evaluation as vaccines for use in humans.
Url:
DOI: 10.1093/infdis/134.6.577
Affiliations:
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Chanock</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7C9B054B746DDDAF13B9CE9A1B0FF48810C8EBFC</idno><date when="1976" year="1976">1976</date><idno type="doi">10.1093/infdis/134.6.577</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-WWJ4JCXN-9/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000639</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000639</idno><idno type="wicri:Area/Istex/Curation">000639</idno><idno type="wicri:Area/Istex/Checkpoint">001684</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001684</idno><idno type="wicri:doubleKey">0022-1899:1976:Murphy B:temperature:sensitive:mutants</idno><idno type="wicri:Area/Main/Merge">002C87</idno><idno type="wicri:Area/Main/Curation">002B17</idno><idno type="wicri:Area/Main/Exploration">002B17</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Temperature-Sensitive Mutants of Influenza A Virus. XI. Transfer of ts Lesions in the Hong Kong/68-<hi rend="italic">ts</hi>-l [A] Virus to the Influenza A/Udorn/72 Wild Type<ref type="fn" target="#fn1"></ref></title><author><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Please address requests for reprints to Dr. Brian R. Murphy, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Room 301, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Tierney, Eveline L" sort="Tierney, Eveline L" uniqKey="Tierney E" first="Eveline L." last="Tierney">Eveline L. Tierney</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Spring, Susan B" sort="Spring, Susan B" uniqKey="Spring S" first="Susan B." last="Spring">Susan B. Spring</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M." last="Chanock">Robert M. Chanock</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1976-12">1976</date><biblScope unit="vol">134</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="577">577</biblScope><biblScope unit="page" to="554">554</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The presence of the temperature-sensitive (ts) lesions of complementation-recombination groups I and 5 in the Hong Kong/68-ts-I[A] virus was confirmed by genetic analysis of ts recombinants of the Hong Kongj68-ts-1 [A] virus and a Udorn / 72 wildtype virus. Three classes of Udorn/72-ts recombinants were found. One class possessed both ts genes of the Hong Kong/68-ts-I[A] parent, a second class possessed the ts lesion characteristic of group I, and a third class possessed the ts lesion of group 5. The Hong Kongj68-ts-1 [AJ parent and the Udorn/72-ts recombinants exhibited a lO,OOO-fold or greater restriction of replication in the lungs of hamsters than did the homologous wild-type virus. All isolates from the lungs and nasal turbinates of recipients of two of the four Udorn/72-ts-I[AJ recombinants contained only ts virus. These two properties, restricted replication and genetic stability after replication in vivo, suggest that the Udorn/72-ts-I[AJ recombinants should be considered for evaluation as vaccines for use in humans.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name></region><name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M." last="Chanock">Robert M. Chanock</name><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><name sortKey="Spring, Susan B" sort="Spring, Susan B" uniqKey="Spring S" first="Susan B." last="Spring">Susan B. Spring</name><name sortKey="Tierney, Eveline L" sort="Tierney, Eveline L" uniqKey="Tierney E" first="Eveline L." last="Tierney">Eveline L. Tierney</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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